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Yamaura K, Ito K-I, Tsukioka K, Wada Y, Makiuchi A, Sakaguchi M, et al
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While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus
Alternatively, microdosing can also be done by taking standard doses less frequently, at longer intervals
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